I need mnemonics for this.



i figure someone from TDUB could come up with something.

the only ones i can remember from undergrad are hexokinase, aldolase, and enolase.
my goal for today is to have all of the pathways memorized and i'll worry about the kinetics of them this week.

if you don't want to help, feel free to post funny pictures and whatnot.

thanks

11/8/2009 12:24:53 PM

damn

no way i could come up with one that long

11/8/2009 12:26:47 PM

Goddamn I love being an English major.

11/8/2009 12:27:10 PM

it's not that i don't want to help, i'm just not smart like you. so here's a funny picture of a baby.

11/8/2009 12:27:12 PM

oh

and i used the mnemonic

american
pussy
seems
to
need
deeper
penetration

once, lol

11/8/2009 12:27:50 PM

11/8/2009 12:28:24 PM

Hell yeah. My friend makes about 110,000 as a pharmacist at a local supermarket ( chained in a few states).

11/8/2009 12:30:51 PM

ok, i know hexokinase

the second one im using the 6's
glucose 6 phosphate
to
fructose 6 phosphate
is catalyzed by
phosphogluco (for glucose being first) isixer ase

which translates into phosphoglucoisomerase

11/8/2009 12:31:24 PM

my eyes! my eyes!!


that damn pathway made my eyes start bleeding

brings back horrid memories of dr sylvia

*twitch* *twitch*

11/8/2009 12:31:28 PM

ah, glycolysis... I wish I could help you out


I just made some mnemonics for the amino acids you can make from each of the intermediate steps (as well as in the TCA cycle), but I don't have anything for this specifically

11/8/2009 12:31:43 PM

11/8/2009 12:31:48 PM

photographic memory would make this much easier

11/8/2009 12:32:16 PM

ok, kinases transfer phosphate groups

so phosphofructokinase transfers a phosphate to carbon 1 (im assuming) to fructose 6 kinase

[Edited on November 8, 2009 at 12:35 PM. Reason : fhfg]

11/8/2009 12:34:57 PM

I've already forgotten all of this from Dr. Hardin class and it was only last spring. :/

11/8/2009 12:35:14 PM

keep it simple with 3 easy steps

1.glycolysis-the six glucose gets oxidized into pruvates (3 carbon chains)
2.krebs cycle-pyruvates get oxidized into co2
3.i forgot- something with electrons and polarized charge to make atp or some shit

11/8/2009 12:35:50 PM

^yeah, thats basics.



i need to know the individual kinetics of each step.
in all pathways.

(and im pretty sure the third one is electron transport chain)

[Edited on November 8, 2009 at 12:38 PM. Reason : dfgfd]

11/8/2009 12:37:46 PM

Substrates:
Gorgeous Girls *uck Fine Gentlemen Gently But Prohibit Penile Pooper Penetration

Enzymes:
Hot Poontang Practically Always Takes Great Patience Preparing Eventual Penetration



also:

http://www.medicalmnemonics.com/

11/8/2009 12:41:10 PM

lol

[Edited on November 8, 2009 at 12:42 PM. Reason : 10/10]

11/8/2009 12:41:57 PM

^^sweeeeeeeeeeeet. youre aweome


and i am an idiot

isomerases change the form but not the formula.
thats why the 2nd enzyme is an isomerase

[Edited on November 8, 2009 at 12:42 PM. Reason : etrt]

11/8/2009 12:42:13 PM

just write it really small on the inside of a water bottle label.

put label back on bottle.

water magnifies it.

profit.

11/8/2009 2:09:34 PM

it gets worse... that's only a tiny part of....

11/8/2009 6:10:45 PM

So hardcore evolutionists think all that ^ came from some warm amino soup in a lake which got hit by lightning?


[Edited on November 8, 2009 at 6:17 PM. Reason : THREAD DERAILMENT]

11/8/2009 6:17:16 PM

You're right, it's much more likely that an eternal, omniscient, omnipresent being that exists outside of our concept of time and space created everything for purposes both unclear and unknowable. The only thing that we can know for sure is that for some reason it really hates when people fuck without being married.

Hey, Joie why don't you just do what I do whenever I need to memorize something. Take a snapshot of it with your mind and then just recall it when you need to use it again, works great for me especially tables and graphs, those are the easiest.

11/8/2009 7:57:01 PM

I had to memorize this (and a bunch of other crazy pathways) for advanced nutrient metabolism. I just wrote down the first letter/abbreviation of everything and memorized it that way.

g
|
g/h + atp
|
g6p
|
pgi
|
f6p
|
pfk + atp
|
f16p

etc.

then I wrote the abbreviations over and over and over, and read them through as the actual words. good luck, I know how you feel.

11/8/2009 7:59:27 PM

Quote :

" Take a snapshot of it with your mind and then just recall it when you need to use it again, works great for me especially tables and graphs, those are the easiest."

this doesnt work for me.
i suck at memorizing stuff.

now give me concepts and ways to apply them and ill give you something back bad-ass.
not meaning to toot my own horn, but i just work really, really well with actually learning things and then applying them.

but just straight memorizing...doesn't work well for me.

and yes Arab13 - we've seen that poster a million times.
good news-we only need to learn the ones that are major drug targets
bad news-we have to know them inside and out.


ie-for the top image (glycolysis) i have to know not just that, but the kinetic mechanism of each step.
then onto TCA
Electron chain
and i can't remember what else

i think he may push off the TCA until the final.

[Edited on November 8, 2009 at 8:07 PM. Reason : sedfd]

11/8/2009 8:07:11 PM

Sometimes it's nice to have a semi-photographic memory.

11/8/2009 8:09:49 PM

<-----------jealous

11/8/2009 8:14:28 PM

rofl i threw away all of my sylvia notes the instant i finished that class.

11/8/2009 8:17:09 PM

when i need to learn stuff i turn it into a fairy tale. something like...

the glucose tried the glucokinase/hexokinase but it was too cold
so then the glucose tried the phosphogluco1somerase but it was too hot
and then the glucose tried the phosphofructosekinase and it was juuuuuuuuust right

11/8/2009 8:17:18 PM

for my final in that class, it was one question that listed all the pathways we had discussed and asked us to write them all out in a connected/cohesive manner.

11/8/2009 8:20:52 PM

I'm like you Joie, I need to know why I'm learning this, how it applies and such. Once it all clicks I rock that shit but memorizing sucks...

11/8/2009 8:22:24 PM

i like needing to understand things. not memorize things.

11/8/2009 8:23:16 PM

do you just need to know the substraits and products or do you need to memorize the cofactors and steps in ATP and ADP are used and all that jazz?

11/8/2009 9:02:55 PM

probably all of the above.... +"the kinetic mechanism of each step."

also:

Quote :

""What in the world is that?" asked a friend, when I had folded out the poster on the floor of a corridor. "Life," I replied. More than half-a-century ago, the great Austrian physicist Erwin Schrodinger tried a definition of life in a little book called What Is Life? He was convinced that life would eventually be accounted for by physics and chemistry, and his book helped inspire the biomolecular revolution, of which the poster is a momentary snapshot. The best he could come up with was "an elaborate, coherent, meaningful design traced by the great master." Well, here it is, the great design. We will have different ideas about who or what is "the great master." What we know for sure is that life has existed on Earth for nearly 4 billion years, and that all life on Earth (so far described) is related by common descent. As for what got the whole thing going we have only speculations. Let us assume an ancestral living cell, as simple as the simplest bacterium existing today -- an unnucleated blob of protoplasm enclosed by a membrane. Microscopically small. Autopoietic: that is, capable of maintaining itself by chemical interaction with the environment. For billions of years, microbes competed for the opportunity to reproduce. Far more failed than succeeded. Most branches on the tree of life were nipped in the bud. A few lucky lineages eased into the future, avoiding the sweeping scythe of death, like the few stalks of grain that remain standing in a harvested field. In biology textbooks, timelines of the first 3 billion years of life on Earth are mostly blank. Photosynthesis. Respiration. Nucleated cells. Sexual reproduction. It would appear that not much happened. But in fact everything was happening; life was perfecting the complex chemistry that sustains every living creature on Earth today, the reactions we see on the poster. By the time the first multi-celled organisms appeared about 700 million years ago -- and the timeline of Earth history becomes crowded and familiar -- most of the real work of evolution is finished. The basic chemical machinery of autopoiesis and reproduction is in place. Everything that follows -- apple trees, great horned owls, great blue whales -- will be variations on a theme. The Biochemical Pathways poster gives us a glimpse of those first 3 billion years, those delicate lineages fingering into the future, inching forward under the great overarching shadow of death, always bearing the residue of the past, teasing self-maintenance from the environment, transforming the Earth's crust, atmosphere and oceans, competing, occasionally turning exploitation into mutual advantage, perfecting metabolic pathways of astonishing complexity. What is life? Here it is, folded out on the floor of a college corridor."

11/8/2009 10:38:40 PM

I always enjoyed this one for remembering resistor color codes

Bad boys rape our young girls but Violet gives willingly

11/8/2009 10:45:37 PM

"The beauty of a living thing is not the atoms that go into it but the way that those atoms are put together." - Carl Sagan

11/8/2009 10:45:38 PM

i pulled out all my biochem stuff to look at this. I actually really liked this class probably because I can kick some memorization ass

11/8/2009 11:01:10 PM

Quote :

"So hardcore evolutionists think all that ^ came from some warm amino soup in a lake which got hit by lightning?"

don't be stupid

11/9/2009 9:17:36 AM

exactly, some people think it came from god which is far less stupid

11/9/2009 10:30:55 AM

Oh man I feel your pain. I'm in BCH now and this along with gluconeogenesis among various other pathways are all what we have to memorize. I love the class, though. If I come up with anything I shall be sure to pass it along!

11/9/2009 11:01:03 AM

Quote :

"Substrates: Gorgeous Girls *uck Fine Gentlemen Gently But Prohibit Penile Pooper Penetration Enzymes: Hot Poontang Practically Always Takes Great Patience Preparing Eventual Penetration "

or

Quote :

""Goodness Gracious, Father Franklin Did Go By Picking Pumpkins (to) Prepare Pies": Glucose Glucose-6-P Fructose-6-P Fructose-1,6-diP Dihydroxyacetone-P Glyceraldehyde-P 1,3-Biphosphoglycerate 3-Phosphoglycerate 2-Phosphoglycerate (to) Phosphoenolpyruvate [PEP] Pyruvate · 'Did', 'By' and 'Pies' tell you the first part of those three: di-, bi-, and py-. · 'PrEPare' tells location of PEP in the process. Glycolysis enzymes "High Profile People Act Too Glamorous, Picture Posing Every Place": Hexokinase Phosphoglucose isomerase Phosphofructokinase (PFK) Aldase A Triose phosphate isomerase Glyceraldehyde-3-phosphate dehydrogenase Phosphoglycerate mutase Enolase Pyruvate kinase"

11/9/2009 11:35:10 AM

hi there

hows it going

11/10/2009 6:08:01 PM

better.

i have them memorized.
glycolyis, gluconeogenesis, TCA, and Oxidative phosphorylation (alough that one is a bit harder)

except pentose monophosphate pathway.

the steps are throwing me a bit off.
but its coming along ok, i guess.


i keep getting distracted.



[Edited on November 10, 2009 at 6:10 PM. Reason : ytrft]

11/10/2009 6:09:35 PM

stupid pentose phosphate pathway... i get my shit mixed up on that one


haha of course I would be dumbfounded now if you asked me anything about these things today

11/10/2009 6:11:43 PM

i have some great notes on that pentose shunt that really helped me out. Also, i know you said strait up memorization was more difficult for you. Have you tried watching some the the animations that are available on youtube, ect? Personally, I found it really helpful in terms of linking together the big picture and "seeing" the steps instead of just memorizing it.

11/10/2009 6:17:53 PM

^yeah thats what ive been doing.

i can't memorize worth a crap.

11/10/2009 6:19:24 PM

yeah, animations usually helped me, and nowadays everything that the textbooks put on their CD's you can find on youtube

11/10/2009 6:19:29 PM

Quote :

"i suck at memorizing stuff. now give me concepts and ways to apply them and ill give you something back bad-ass"

i am the polar opposite, i wish I had Joie's problem

11/10/2009 6:23:43 PM

I actually learn better her way- but that is because I am a better visual learner... reading or audio don't do much for me (unless my off and on photographic memory can actually remember the text- which does happen about 50% of the time)

11/10/2009 6:25:10 PM

...

[Edited on November 10, 2009 at 6:32 PM. Reason : ]

11/10/2009 6:31:53 PM